The combined efforts of the excellent and complementary participants of the CarDia project will create a comprehensive national research platform (institute) encompassing experimental, preclinical, translational and clinical research activities in the prevention and treatment of CVD, its most common risk factors such as obesity and diabetes, and related chronic complications. This will ultimately help to prevent and treat these diseases more effectively by translating the knowledge gained from experimental research into new treatments and interventions. This will be done in an approach that optimises the situation in the Czech population. The main milestones of the project are: (1) concentration of capacity and launch of the project and its scientific agenda, in 2022; (2) full implementation of the agenda, based on 100 full-time equivalent of scientists and technical staff involved, and obtaining the first scientific results, in 2023; (3) obtaining most of the results and the main development of international collaboration, in 2024; and (4) publication of the results and evaluation of the project, in 2025. Top 100 recipients: Institut klinické a experimentální medicíny Ústav organické chemie a biochemie AV ČR Fyziologický ústav AV ČR Univerzita Karlova Masarykova univerzita Copyright: Ministry of Industry and Trade Reference5.1.I1 in the CZ Recovery and Resilience PlanProject locations Czechia Project websitehttps://www.syri.institute/